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. Author manuscript; available in PMC: 2014 Jul 29.
Published in final edited form as: Cancer Res. 2012 Apr 13;72(12):2937–2948. doi: 10.1158/0008-5472.CAN-11-3368

Figure 2.

Figure 2

Cytokine levels in serum and evidence of bystander effect in leukemic cells from peripheral blood after Ad-ISF35 IDI. A, serum cytokine levels measured over time were assessed using the Luminex assay on each cohort of patients who received Ad-ISF35 IDI. B, CLL cell surface expression of CD95, CD54, CD86, and CD80 was assessed by flow cytometry in vivo and in vitro. Histograms on the left show in vivo data obtained from blood samples collected before (day 0) and 2 days after Ad-ISF35 IDI. Histograms on the right represent the in vitro data obtained after CLL cells were cultured with autologous serum collected before (pre) and 1 day (highest levels of IFN-γ and IL-6) after Ad-ISF35 IDI. As a control, CLL cells were cocultured with HeLa cells expressing CD154 (CD154 stimulation).