Table 2.
Tissue distribution of ProstaScint™ in NCr nude mice bearing LNCaP xenografts.
| Time (hr) | |||||
|---|---|---|---|---|---|
| Tissue | 1 | 4 | 24 | 48 | 72 |
| Blood | 30.8 ± 7.6 | 29 ± 5.2 | 15.5 ± 5 | 11.8 ± 0.9 | 10.8 ± 7.5 |
| Heart | 8.47 ± 1.17 | 7.87 ± 2.09 | 4.39 ± 1.08 | 2.7 ± 0.37 | 1.76 ± 0.36 |
| Lungs | 19.46 ± 2.65 | 15.07 ± 2.85 | 9.04 ± 2.52 | 6.57 ± 1.89 | 4.75 ± 0.73 |
| Liver | 16.7 ± 4.5 | 14.1 ± 2 | 10.2 ± 1.8 | 8.31 ± 1.87 | 7.87 ± 1.31 |
| Spleen | 9.96 ± 2.77 | 8.91 ± 2.44 | 8.61 ± 1.44 | 8.62 ± 1.87 | 8.39 ± 3.81 |
| Kidneys | 8.7 ± 1.5 | 8.7 ± 1.1 | 9 ± 1.2 | 9.8 ± 1 | 10.9 ± 3.4 |
| Stomach | 1.05 ± 0.25 | 1.26 ± 0.53 | 1.08 ± 0.41 | 0.82 ± 0.13 | 0.77 ± 0.25 |
| Lg Intestine | 0.76 ± 0.12 | 1.47 ± 0.34 | 2.68 ± 0.89 | 1.49 ± 0.91 | 1.01 ± 0.34 |
| Sm Intestine | 2.44 ± 0.5 | 3.23 ± 0.23 | 2.07 ± 0.44 | 1.82 ± 0.91 | 1.49 ± 0.29 |
| Testes | 1.73 ± 0.35 | 2.82 ± 0.39 | 1.96 ± 0.56 | 1.55 ± 0.2 | 1.45 ± 0.54 |
| Sk.Muscle | 0.85 ± 0.57 | 0.66 ± 0.18 | 0.96 ± 0.28 | 0.84 ± 0.08 | 0.76 ± 0.19 |
| Bone | 2.42 ± 0.59 | 2.58 ± 0.86 | 2.04 ± 0.47 | 1.64 ± 0.36 | 1.34 ± 0.4 |
| Brain | 0.66 ± 0.13 | 0.96 ± 0.69 | 0.38 ± 0.13 | 0.26 ± 0.02 | 0.23 ± 0.09 |
| Adipose | 2.13 ± 0.49 | 1.54 ± 0.71 | 2.16 ± 0.31 | 1.93 ± 0.52 | 1.57 ± 0.46 |
| Tumor | 3.33 ± 1.13 | 7.92 ± 3.17 | 21.8 ± 10.2 | 27.8 ± 10.4 | 31.4 ± 20.1 |
Data are %ID/g, expressed as mean ± SD.