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. Author manuscript; available in PMC: 2014 Jul 29.
Published in final edited form as: Curr Pharm Des. 2007;13(15):1607–1616. doi: 10.2174/138161207780765918

Table 2.

Serine Protease Inhibitors Possibly Involved in the Pathogenesis of Alzheimer’s Disease

Serpins Functions Expression in Alzheimer’s Disease Reference
Alfa1-antichymotrypsin Acute-phase protein in inflammation Increase in senile plaques [100]
Alfa1-antitrypsin Acute-phase protein in inflammation Increase in senile plaques [101]
Antithrombin Destruction of released coagulation proteases, natural anticoagulant Increase in senile plaques [74]
Plasminogen activator inhibitor Inhibition of plasminogen activator; regulation of fibrinolysis Increase in senile plaques [102]
Protease nexin I Natural anticoagulant in the central nervous system decrease in the brain Increase in senile plaques, [103]
Tissue factor pathway inhibitor Inhibition of tissue factor and factor Xa; natural anticoagulant Elevation in frontal cortex [75]