Table 1.

Groups of children included in histological (in vitro) and MRI (in vivo) study with classification of lesion on MRI according to SCPE grading system.

Groups	Methods	Type of lesion	Number of cases		MRI1	MRI2
			Unilateral	Bilateral
Premature and term children with pathology	In vivo MRI (23–42 PCW)	Non-cystic periventricular leukomalacia (27–30 PCW)	2	8	+	+
		Cystic periventricular leukomalacia (27–33 PCW)	2	2	+	+
		Intraventricular/periventricular hemorrhage (23–39 PCW)	1	4	+	+
		Moderate basal ganglia/thalamus/cortex lesion (40–42 PCW)	0	2	+	+
	In vitro histology (22–44 PCW)		7
Normotypic prematures	In vivo MRI (24–31 PCW)		11		+	+
	In vitro histology (26–34 PCW)		12
Normal term children	In vivo MRI (39–41 PCW)		4		+	−
	In vitro histology (39–41 PCW)		2

Number in parenthesis refers to PCW age range at birth. First MRI exam (MRI1) was performed at term or term equivalent age and the second MRI (MRI2) exam was performed during period between first and third years.