Table 3. Characteristics of Patients Transitioned to Airway Pressure Release Ventilation (n = 29) and High-Frequency Oscillatory Ventilation (n = 31).
| Airway Pressure Release Ventilation | High-Frequency Oscillatory Ventilation | |||||
|---|---|---|---|---|---|---|
|
|
|
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| Variablea | Survivors (n = 11) | Nonsurvivors (n = 18) | pb | Survivors (n = 11) | Nonsurvivors (n = 20) | pb |
| Age (yr) | 10.8 [4.3, 17.2] | 10.4 [4.0, 18.7] | 0.946 | 3.0 [1.7, 6.8] | 3.4 [1.1, 6.5] | 0.951 |
|
| ||||||
| Pediatric Risk of Mortality version III at 24 hr | 17 [12, 19] | 12 [8, 20] | 0.174 | 17 [3, 22] | 15 [6, 21] | 0.860 |
|
| ||||||
| Before switch to NCV | ||||||
| mPaw (cm H2O) | 19 [16, 23] | 24 [21, 26] | 0.096 | 21 [18, 23] | 22 [20, 23] | 0.207 |
| Pao2/Fio2 | 87 [63, 117] | 98 [69, 111] | 0.980 | 78 [60, 96] | 73 [58, 84] | 0.409 |
| OIpre | 20.4 [17.1, 25.4] | 28.5 [20.0, 31.5] | 0.327 | 25.0 [22.3, 29.4] | 30.0 [24.8, 38.0] | 0.193 |
| Paco2 | 58 [53, 66] | 61 [49, 70] | 1 | 81 [74.5, 100.5] | 85 [73, 116.5] | 0.788 |
|
| ||||||
| Lung disease (%) | ||||||
| Viral pneumonia | 1 (9) | 11 (61) | 4 (36%) | 9 (45%) | ||
| Bacterial pneumonia | 2 (18) | 1 (5.5) | 2 (18%) | 1 (5%) | ||
| Fungal pneumonia | 2 (18) | 2 (11) | 0.158 | 1 (9%) | 3 (15%) | 0.389 |
| Alveolar hemorrhage | 1 (9) | 1 (5.5) | 0 | 3 (15%) | ||
| Sepsis | 3 (27) | 2 (11) | 3 (27%) | 4 (20%) | ||
| Other | 2 (18) | 1 (5.5) | 1 (9%) | 0 | ||
|
| ||||||
| Vasopressor infusions (%) | ||||||
| <2 | 5 (45) | 4 (22) | 0.237 | 3 (27%) | 4 (20%) | 0.676 |
| ≥ 2 | 6 (55) | 14 (78) | 8 (73%) | 16 (80%) | ||
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| ||||||
| Stem cell transplant (%) | ||||||
| Allogeneic | 2 (18) | 10 (56) | 0.110 | 1 (73%) | 8 (40%) | 0.199 |
| Autologous | 2 (18) | 2 (11) | 2 (9%) | 2 (10%) | ||
| None | 7 (64) | 6 (33) | 8 (18%) | 10 (50%) | ||
|
| ||||||
| After 24 hr of NCV | ||||||
| mPaw (cm H2O) | 26 [24, 28] | 31 [28, 37] | 0.012 | 31 [27, 32] | 33 [31, 35] | 0.076 |
| PF | 248 [198, 309] | 115 [88, 159] | < 0.001 | 224 [145, 309] | 101 [69, 138] | < 0.001 |
| PF24/PFpre | 2.8 [1.9, 3.8] | 1.3 [0.9, 1.6] | 0.001 | 2.7 [2.2, 3.2] | 1.2 [0.9, 1.5] | < 0.001 |
| OI24 | 11.8 [8.3, 13.0] | 29.7 [18.3, 35.2] | < 0.001 | 14.3 [9.2, 22.0] | 33.7 [25.0, 52.2] | < 0.001 |
| OI24/OIpre | 0.5 [0.4, 0.7] | 1 [0.8, 1.7] | < 0.001 | 0.5 [0.4, 0.7] | 1.3 [1.0, 1.6] | < 0.001 |
| Paco2 | 43 [40, 56] | 49 [43, 54] | 0.300 | 48 [45, 56.5] | 59 [51, 64.5] | 0.102 |
NCV = nonconventional ventilation, mPaw = mean airway pressure, OI = oxygenation index, PF = Pao2/Fio2
a
Continuous data are in the form of median [25th and 75th percentile], and categorical data are in the form of n (%)
b
Medians are compared using a Wilcoxon rank-sum test for unpaired data. Categorical variables are compared using a Fisher exact test.