Table 3.
Risk of recurrent ischemic stroke by levels of high-sensitivity C-reactive protein before and after adjusting for potential confounders
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| HsCRP continuous (per SD) | 1.09[0.93,1.28] | 0.27 | 1.11[0.94,1.32] | 0.21 | 1.11[0.93,1.32] | 0.25 | 1.12[0.93,1.34] | 0.22 |
| HsCRP | 0.05 | 0.04 | 0.09 | 0.11 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 1.94[0.96,3.95] | 2.03[0.99,4.13] | 2.08[1.02,4.26] | 2.07[1.01,4.23] | ||||
| Quartile 3 | 1.66[0.81,3.40] | 1.85[0.90,3.81] | 1.91[0.92,3.96] | 1.95[0.94,4.05] | ||||
| Quartile 4 | 2.54[1.30,4.96] | 2.68[1.36,5.26] | 2.46[1.22,4.95] | 2.32[1.15,4.68] | ||||
| HsCRP (Standard clinical thresholds) | 0.04 | 0.03 | 0.05 | 0.06 | ||||
| <1 mg/L (Referent) | -- | -- | -- | -- | ||||
| 1–3 mg/L | 1.75[0.90,3.38] | 1.83[0.94,3.55] | 1.82[0.94,3.56] | 1.82[0.94,3.55] | ||||
| >3 mg/L | 2.20[1.19,4.10] | 2.36[1.26,4.42] | 2.22[1.17,4.24] | 2.16[1.13,4.11] | ||||
| HsCRP | 0.55 | 0.62 | 0.61 | 0.65 | ||||
| ≤15 mg/L (Referent) | -- | -- | -- | -- | ||||
| >15 mg/L | 1.29[0.56,2.95] | 1.24[0.54,2.85] | 1.24[0.54,2.88] | 1.22[0.52,2.83] | ||||
Abbreviations: hsCRP= high-sensitivity C-reactive protein; HR= hazard ratio; 95% CI= 95% confidence interval; SD=standard deviation
Models:
- Unadjusted
- Adjusted for Demographics (Age, Sex, Race, Region)
- Adjusted for Demographics (Age, Sex, Race, Region) and Co-morbidities (Hypertension, Smoking, History of Ischemic Stroke, Diabetes, Body mass index, Low- density lipoprotein and High-density lipoprotein)
- Adjusted for Demographics (Age, Sex, Race, Region), Co-morbidities (Hypertension, Smoking, History of Ischemic Stroke, Diabetes, Body mass index, Low- density lipoprotein and High-density lipoprotein), and Statin use at baseline