Table 5.
Risk of major vascular events (stroke, myocardial infarction, vascular death) by levels of high-sensitivity C-reactive protein before and after adjusting for potential confounders
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95%) | p | HR (95%) | p | HR (95%) | p | HR (95%) | p | |
| HsCRP continuous (per SD) | 1.07[0.92,1.24] | 0.39 | 1.08[0.93,1.25] | 0.34 | 1.08[0.92,1.26] | 0.36 | 1.08[0.92,1.27] | 0.34 |
| HsCRP | 0.05 | 0.04 | 0.07 | 0.09 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 1.91[1.07,3.41] | 1.92[1.07,3.44] | 1.95[1.08,3.50] | 1.95[1.08,3.50] | ||||
| Quartile 3 | 1.53[0.85,2.77] | 1.63[0.90,2.97] | 1.60[0.87,2.94] | 1.63[0.89,2.99] | ||||
| Quartile 4 | 2.14[1.22,3.75] | 2.24[1.27,3.94] | 2.12[1.18,3.81] | 2.04[1.14,3.67] | ||||
| HsCRP (Standard Cut-offs) | 0.08 | 0.05 | 0.11 | 0.12 | ||||
| <1 mg/L (Referent) | -- | -- | -- | -- | ||||
| 1–3 mg/L | 1.50[0.88,2.56] | 1.52[0.89,2.60] | 1.52[0.89,2.60] | 1.53[0.89,2.61] | ||||
| >3 mg/L | 1.77[1.07,2.93] | 1.87[1.13,3.10] | 1.75[1.04,2.94] | 1.72[1.02,2.90] | ||||
| HsCRP | 0.34 | 0.38 | 0.35 | 0.37 | ||||
| ≤15 mg/L (Referent) | -- | -- | -- | -- | ||||
| >15 mg/L | 1.40[0.71,2.76] | 1.36[0.68,2.69] | 1.40[0.69,2.72] | 1.37[0.69,2.74] | ||||
Abbreviations: hsCRP= high-sensitivity C-reactive protein; HR= hazard ratio; 95% CI= 95% confidence interval; SD=standard deviation
Models:
- Unadjusted
- Adjusted for Demographics (Age, Sex, Race, Region)
- Adjusted for Demographics (Age, Sex, Race, Region) and Co-morbidities (Hypertension, Smoking, History of Ischemic Stroke, Diabetes, Body mass index, Low- density lipoprotein and High-density lipoprotein)
- Adjusted for Demographics (Age, Sex, Race, Region), Co-morbidities (Hypertension, Smoking, History of Ischemic Stroke, Diabetes Body mass index, Low- density lipoprotein and High-density lipoprotein), and Statin use at baseline