Figure 1.
Proposed mechanisms of the formation of the cyclic adducts studied in this work induced by PUFAs through hydroperoxy fatty acids (FAOOH): α-OH-1,N2-propano-2′-deoxyguanosine (α-OHPdG), γ-OH-1,N2-propano-2′-deoxyguanosine (γ-OHPdG) 1,N6-ethenodeoxyadenosine (edA), 7-(1′,2′-dihydroxyheptyl)-1,N6-ethenodeoxyadenosine (DHHedA), and trans-4-hydroxy-2-noenal-deoxyguanosine (HNE-dG).