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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 May 6;73:12–20. doi: 10.1016/j.freeradbiomed.2014.04.032

Figure 3.

Figure 3

Detection of DHHedA in LEC rat liver and human liver DNA by the LC-MS/MS method. Three double panels show mass chromatograms from three experiments. Top one shows mass chromatograms for the synthetic DHHedA standard (406.2 → 290.2 m/z) and [15N5]-DHHedA internal standard (411.2 → 295.1 m/z); 29.7 fmol of each DHHedA 1,2 and 3,4 standards and 37 fmol for each [15N5]-DHHedA 1,2 and 3,4 internal standards. The middle panel presents mass chromatograms obtained from DNA of normal human liver (4.8 fmol of DHHedA 1,2 and 12.1 fmol of DHHedA 3,4 detected). The bottom panel presents mass chromatograms for DNA from LEC rat liver (12.1 fmol of DHHedA 1,2 and 21.1 fmol of DHHedA 3,4 detected).