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Neonatal maternal separation and IL-10 deficiency cause long-term alterations in colonic barrier function. NMS caused significant increases in mucosal-to-serosal FITC-dextran flux in wild type and IL-10-/- mice (b,c: p<0.05). Effects of NMS and IL-10 deficiency were additive in causing increased permeability (c) (n=8/group).
