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. Author manuscript; available in PMC: 2014 Jul 29.
Published in final edited form as: Brain Res. 2012 Jan 3;1440:1–8. doi: 10.1016/j.brainres.2011.12.034

Figure 4. Increased Frequency of Spontaneous Miniature IPSCs in Ts65Dn.

Figure 4

(A) Frequency histograms of miniature IPSCs recorded in the presence of TTX (1µM), NBQX (10 µM) and AP5 (50 µM). Each histogram represents average mIPSCs (1 pA bins, means ± SEM) from n=7, 2N and n=5, Ts65Dn, where ‘n’ represents the number of animals used and is an average of recordings from 1–3 slices per animal. The total frequency of mEPSCs was significantly increased in recordings from Ts65Dn compared with 2N mice (unpaired Student's t test, P < 0.05). Open circles are events collected from 2N slices, closed circles from Ts65Dn slices. Scale bars for inset traces are 20 pA, 500 ms.

(B) Cumulative histogram of mIPSC amplitude. No difference in mIPSC amplitude was noted between the 2N and Ts65Dn groups. Open circles, 2N; filled circles, Ts65Dn. The error bars in A and B represent SEM.