Figure 2. GTx SARMs inhibit triple negative breast cancer xenograft growth in nude mice.
A and B. MDA-MB-231-AR cells (5 million cells/mouse) were mixed with matrigel and implanted subcutaneously in female nude mice (n = 8). Once tumors reached 200-300 mm3, animals were randomized and treated orally with vehicle or 30 mg/kg/day GTx-027. Tumor volumes (A) were measured thrice weekly. Five weeks after initiation of treatment, the animals were sacrificed, tumors weighed (B) and stored for various analyses. C. GTx-027 and GTx-024 inhibit tumor growth and increase body weight gain. Nude mice xenograft was performed as indicated in panel A (n = 8) with dose response of GTx-027 and GTx-024. Tumor volumes (top left panel) and body weights (bottom panel) were measured thrice weekly. At sacrifice, tumors were weighed (top right panel) and stored for further analyses. TGI-Tumor growth inhibition; *-p<0.05; ***-p<0.001. Results are represented as mean ± S.E.