Table 1.

Polymorphisms with the lowest P values for association with sensory peripheral neuropathy

	Case/control	Entire genomea				Neuropathy-associated genesa,b
		Gene	Polymorphism	Odds ratio	P value	Gene	Polymorphism	Odds ratio	P value
Grade ≥1	90/164	KRR1	rs11540407	2.6	9.6 × 10−6	FGD4	rs1909509	2.1	9.6 × 10−4
		Intergenic	rs9518599	2.5	1.1 × 10−5	FGD4	rs7298165	1.9	1.8 × 10−3
		KRR1	rs1552039	2.6	1.1 × 10−5	FGD4	rs6488066	1.9	2.2 × 10−3
		ACE2	rs1514280	3.6	1.2 × 10−5	RAD52	rs1051669	1.8	3.4 × 10−3
		KRR1	rs2070162	2.6	1.3 × 10−5	NDRG1	rs2930004	1.7	4.3 × 10−3
Grade ≥2	58/164	SASH1	rs8641	3.1	5.8 × 10−6	FAM134B c	rs149511	0.4	4.7 × 10−3
		SASH1 c	rs208740	2.9	9.0 × 10−6	FGD4	rs1909509	2.1	5.4 × 10−3
		ST8SIA2 c	rs12913269	3.4	1.3 × 10−5	WISP1	rs2929965	0.5	5.6 × 10−3
		ST8SIA2 c	rs2129797	3.4	1.4 × 10−5	LITAF c	rs12595973	0.5	7.7 × 10−3
		NTF3	rs6332	2.7	1.7 × 10−5	KIF1A c	rs4234121	0.4	9.2 × 10−3
Grade 3	23/164	ST8SIA2 c	rs12913269	6.5	3.2 × 10−7	KIF1B c	rs11587309	2.7	5.1 × 10−3
		ST8SIA2 c	rs2129797	6.4	3.5 × 10−7	KIF1A	rs10198394	2.4	7.3 × 10−3
		Intergenic	rs4397851	5.3	1.5 × 10−6	NDRG1	rs10505606	2.4	7.7 × 10−3
		ADAMTS2	rs6873892	6.1	2.1 × 10−6	NDRG1	rs2233326	2.4	1.1 × 10−2
		ST8SIA2 c	rs12910290	5.1	2.8 × 10−6	KIF1B	rs10492970	7.1	1.1 × 10−2

^aMeta-analyses were performed to combine results from White, Black, and Hispanic groups

^bThe neuropathy-associated genes from the Inherited Peripheral Neuropathies Mutation Database plus DNMT1 and KIF1A are listed in Supplemental On-line Table 1

^cThese polymorphisms are within 100 kb of the named gene