Table 2.

Antiproliferative activity of polymethoxylated N-benzoyl THIQs against DU-145 human prostate cancer cells and MDA MB-231 human breast cancer cells in vitro

Compd					GI50 [μm][a]
	R1	R3	R4	R5	DU-145	MDA MB-231
14 e	Bn	OMe	OMe	H	26.7	ND[b]
18 a	H	OMe	OMe	H	>100	ND[b]
19 a	SO2NH2	OMe	OMe	H	>100	ND[b]
14 f	Bn	OMe	H	OMe	46.8	ND[b]
18 b	H	OMe	H	OMe	6.4	ND[b]
19 b	SO2NH2	OMe	H	OMe	9	ND[b]
14 g	Bn	OMe	OMe	OMe	62.7	18.9
18 c[c]	H	OMe	OMe	OMe	0.921	0.733
19 c[c]	SO2NH2	OMe	OMe	OMe	1.81	1.72

[a] Results are the mean of three determinations. [b] Not determined. [c] Data for 18 c and 19 c are taken from the literature.[8]