Table 2.
Model parameters (confidence intervals of fitting) for cerebral blood flow (CBF) response to hypoxia
| CBFB (mL/100 g/min) | CBFH (mL/100 g/min) | CBFR (mL/100 g/min) | kH (s–1) | kR(s–1) | δH (s) | δR (s) | |
|---|---|---|---|---|---|---|---|
| All grey matter | 76.1 | 87.8 | 76.4 | 0.0035 | 0.0069 | 185 | 20* |
| (75.5, 76.7) | (86.7, 89.6) | (73.8, 78.7) | (0.0019, 0.0046) | (0.002, 0.0103) | (132, 230) | (–38,38) | |
| Frontal lobe | 56.9 | 68.2 | 57.0 | 0.0032 | 0.005 | 250 | 20 |
| (56.4, 57.4) | (66.8, 69.7) | (53.6, 60.5) | (0.0018, 0.0046) | 0.0008, 0.0091) | (202, 298) | (–26, 65) | |
| Insula | 71.1 | 83.4 | 73.9 | 0.0034 | 0.0132 | 83 | 121 |
| (70.0, 72.2) | (82.0, 84.5) | (71.6, 76.2) | (0.0017, 0.005) | (-0.0019, 0.0284) | (12, 153) | (80, 163) | |
| Occipital lobe | 89.8 | 101.8 | 89.5 | 0.0035 | 0.0099 | 46 | 20 |
| (88.9, 90.7) | (100.6, 102.9) | (87.9, 91.1) | (0.0021, 0.005) | (0.0038, 0.016) | (–8, 100) | (–10, 50) | |
| Parietal lobe | 66.7 | 76.3 | 65.9 | 0.0042 | 0.0062 | 159 | 88 |
| (66.1, 67.2) | (75.6, 77.0) | (62.6, 69.2) | (0.0027, 0.0058) | (0.0008, 0.0116) | (115, 203) | (49, 128) | |
| Putamen | 62.8 | 72.5 | 60.9 | 0.003 | 0.0052 | 83 | 30 |
| (62.1, 63.4) | (71.4, 73.6) | (57.6, 64.2) | (0.0018, 0.0043) | (0.0012, 0.0093) | (26, 140) | (–10, 70) | |
| Temporal lobe | 77.4 | 87.1 | 77.1 | 0.0029 | 0.0062 | 85 | 20 |
| (76.5, 78.2) | (85.5, 88.8) | (73.9, 80.3) | (0.0012, 0.0045) | (0.000, 0.0124) | (7, 163) | (–34, 74) | |
| Thalamus | 62.4 | 71.8 | 59.3 | 0.0044 | 0.0098 | 67 | 20 |
| (61.8, 63.1) | (71.0, 72.5) | (58.0, 60.6) | (0.0027, 0.0062) | (0.0051, 0.0144) | (20, 115) | (–3, 43) |
CBFB, baseline CBF; CBFH, equilibrium CBF during hypoxia; CBFR, recovery CBF; kH, rate constant in the transition to hypoxia; kR, rate constant in the return to normoxia; δH, delay in hypoxia response; δR, delay in response on return to normoxia (refer to Fig. 1).
Delay value fitted at the lower boundary.
Regional data based on 11 subjects.