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miR in HBV-related HCC. In HBV-related HCC, the inhibition of miR-152 resulted in global DNA hypermethylation and increased the methylation levels of two tumor suppressor genes, GSTP1 and CDH1. miR-101 was also downregulated and induced aberrant DNA methylation by targeting DNMT3a. miR, microRNA; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; GSTP, glutathione S-transferase P; CDH1, E-cadherin 1; DNMT, DNA methyltransferase.
