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DNA methylation in the cell cycle. In hepatocellular carcinoma, the tumor suppressor gene, DLEC1 induces a G1 arrest in the cell cycle, while tumor suppressors, UCHL1 and FBP1 result in cell cycle arrest in the G2/M phase. When these genes are silenced by DNA methylation, their functions are inhibited. DLEC1, deleted in lung and esophageal cancer 1; UCHL1, ubiquitin carboxyl-terminal hydrolase L1; FBP1, fructose-1,6-bisphosphatase-1.
