Table II.
Diagnostic characteristics of urine protein, Cat D and Cat D/protein ratio compared with various parameters of urothelial cancer.
| Cat D (ng/ml) | Cat D/protein (ng/mg) | ||||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Parameter | n | Range | Mean±SD | P-value | Range | Mean±SD | P-value |
| Primary/recurrent | NS | <0.01 | |||||
| Primary | 33 | 2.51–4.35 | 3.41±0.95 | 5.25–12.5 | 9.48 ±2.28 | ||
| Recurrent | 35 | 2.25–5.31 | 3.09±0.93 | 2.68–7.28 | 4.23±1.19 | ||
| Multiplicity | NS | <0.01 | |||||
| Single | 22 | 2.42–5.19 | 3.46±1.01 | 5.60–9.29 | 8.65±1.35 | ||
| Multiply | 46 | 2.15–5.31 | 2.90±0.94 | 4.13–8.36 | 6.59±1.68 | ||
| Stage | NS | NS | |||||
| Superficial (Ta+T1) | 47 | 2.90–5.85 | 3.21±0.76 | 3.90–11.60 | 7.64±2.72 | ||
| Invasive (T2+T3=T4) | 21 | 1.35–7.14 | 3.57±1.80 | 4.85–9.10 | 6.15±1.69 | ||
| Grade | NS | <0.01 | |||||
| Low-grade | 22 | 2.42–4.35 | 3.41±0.70 | 8.96–16.10 | 13.37±2.72 | ||
| High-grade | 46 | 1.79–6.32 | 3.45±1.26 | 7.16–10.70 | 8.02±1.42 | ||
| Size (mm) | NS | <0.01 | |||||
| <30 | 39 | 1.85–7.14 | 3.69±1.49 | 9.20–14.20 | 11.8±1.75 | ||
| >30 | 29 | 2.55–6.32 | 3.52±1.14 | 6.43–12.15 | 9.78±2.14 | ||
| Gender | NS | NS | |||||
| Female | 20 | 1.89–6.32 | 3.77±1.59 | 7.37–11.15 | 8.77±1.29 | ||
| Male | 48 | 2.42–7.14 | 3.51±1.20 | 6.09–10.80 | 8.36±1.69 | ||
| Age (years) | NS | <0.05 | |||||
| <65 | 35 | 1.89–7.14 | 3.39±1.43 | 6.91–14.50 | 9.68±2.89 | ||
| ≥65 | 33 | 2.55–6.32 | 3.84±1.14 | 5.90–9.10 | 7.38±1.69 | ||
Total protein concentration was determined by Lowry’s method. Cat D, cathepsin D; SD, standard deviation; NS, not significant.