Table II.
Genotypic and allelic distributions of the p38β gene polymorphism (−1628A→G) regarding tumour location and disease stage in patients with CRC.
| A, Genotype | ||||
|---|---|---|---|---|
|
| ||||
| Location | Stage | |||
|
|
|
|||
| A→G | Colon % (n) | Rectum % (n) | Dukes’ A + B % (n) | Dukes’ C + D % (n) |
| A/A | 28.4 (62) | 28.1 (48) | 28.2 (59) | 28.3 (51) |
| A/G | 45.0 (98) | 46.2 (79) | 46.0 (96) | 45.0 (81) |
| G/G | 26.6 (58) | 25.7 (44) | 25.8 (54) | 26.7 (48) |
| Total | (218) | (171) | (209) | (180) |
|
| ||||
| B, Allele | ||||
|
| ||||
| Location | Stage | |||
|
|
|
|||
| Variant | Colon % (n) | Rectum % (n) | Dukes’ A + B % (n) | Dukes’ C + D % (n) |
|
| ||||
| A | 50.9 (222) | 51.2 (175) | 51.2 (214) | 50.8 (183) |
| G | 49.1 (214) | 48.8 (167) | 48.8 (204) | 49.1 (177) |
| Total | (436) | (342) | (418) | (360) |
Colon vs. rectum and Dukes’ A + B vs. Dukes’ C + B: Genotype and allele distribution, no significant differences (P>0.05). CRC, colorectal cancer.