Table 1. Correlation between baseline expression levels of IFIGs (N=20) and response-toxicity outcomes.

For control reasons, evaluation of gene expression of Interferon inducible genes (IFIGs, N=20) was performed using a bDNA multiplex assay (QGP 1.0, Panomics^®). Only expression of Interferon stimulated exonuclease gene 20kDa (ISG20) differed significantly in all comparisons (P<0.035) before initiation of therapy with pegylated Interferon-α and ribavirin (PegIFN-α/RBV). Gene names and symbols listed in this table correspond to terms explained in EntrezGene: http://www.ncbi.nlm.nih.gov/gene

	overall ANOVA P-value	NR-NoPsAE vs. NR-PsAE	NR-NoPsAE vs. SVR-PsAE	NR-PsAE vs. SVR-PsAE
Gene Symbol	P-value	P-value	P-value	P-value
TRIM5	9.64E-05	0.618378	5.35E-05	0.000242357
APOBEC3G	0.000130875	0.416413	5.37E-05	0.000526096
OAS2	0.00118548	0.481903	0.000462119	0.00316296
IFIT1	0.00125874	0.268183	0.000371204	0.00669527
ISG20	0.000180288	0.0343525	3.93E-05	0.0103719
OAS1	0.00708266	0.579752	0.00281471	0.0120099
IFITM1	0.00399497	0.380528	0.00129636	0.0122214
IFIT3	0.0784446	0.497076	0.0278317	0.115344
MX1	0.0556843	0.335928	0.0177016	0.132397
MX2	0.0628115	0.341076	0.0201968	0.144085
STAT1	0.282406	0.930856	0.149474	0.183131
EIF2AK2	0.0879966	0.301756	0.0290891	0.216966
ISG15	0.0760249	0.260831	0.0246772	0.223032
IFI44	0.20454	0.428514	0.0779284	0.31044
PLSCR1	0.725129	0.812797	0.570623	0.438556
LY6E	0.208519	0.206418	0.0943669	0.640991
APOBEC3A	0.80747	0.532544	0.893426	0.644969
SP110	0.832107	0.841938	0.552333	0.694313
IFI27	0.803717	0.752103	0.513094	0.732396
IRF7	0.704648	0.412934	0.624917	0.763441

[SVR: sustained viral response; NR: viral non-response; PsAE: IFN-α induced psychiatric adverse effects; NoPsAE: No psychiatric adverse effects]