Table 2. Multiple Logistic Regression Analyses for IL1R2, IL10, and TNFA Candidate Gene Markers.
| GMM Class Comparison | Predictor | Odds Ratio | Standard Error | 95% CI | Z | p-value |
|---|---|---|---|---|---|---|
| CES-D Resilient versus Subsyndromal (n=211) | IL1R2 Haplotype A1 | 2.10 | 0.679 | 1.117, 3.959 | 2.30 | 0.021 |
| Age | 0.74 | 0.064 | 0.626, 0.880 | -3.43 | 0.001 | |
| KPS | 0.53 | 0.084 | 0.393, 0.727 | -3.99 | <0.001 | |
| Overall model fit: χ2 = 47.5, p <.0001 R2 = 0.1709 | ||||||
| CES-D Resilient versus Subsyndromal (n=211) | IL10 Genotype | 3.91 | 2.544 | 1.091, 14.000 | 2.09 | 0.036 |
| Age | 0.74 | 0.065 | 0.620, 0.875 | -3.48 | 0.001 | |
| KPS | 0.54 | 0.084 | 0.401, 0.734 | -3.97 | <0.001 | |
| Overall model fit: χ2 = 46.6, p < .0001 R2 = 0.1677 | ||||||
| CES-D Resilient versus Subsyndromal (n=211) | TNFA Genotype 1 | 4.50 | 2.821 | 1.319, 15.373 | 2.40 | 0.016 |
| TNFA Genotype 2 | 0.43 | 0.180 | 0.192, 0.979 | -2.01 | 0.044 | |
| Age | 0.74 | 0.065 | 0.624, 0.881 | -3.40 | 0.001 | |
| KPS | 0.58 | 0.090 | 0.425, 0.783 | -3.53 | <0.001 | |
| Overall model fit: χ2 = 55.0, p < .0001 R2 = 0.1977 | ||||||
Multiple logistic regression analysis for the two GMM groups (i.e., Resilient versus Subsyndromal) based on Center for Epidemiological Studies - Depression Scale total score. For each model, the first three principal components identified from the analysis of ancestry informative markers as well as self-report race/ethnicity were retained in all models to adjust for potential confounding due to race or ethnicity (data not shown). Predictors evaluated in each model included genotype (IL1R2 haplotype A1 composed of rs4141134-rs11674595-rs7570441: zero, one, or two doses of the C-T-G haplotype; IL10 rs1518111: GG + GA versus AA; TNFA rs2229094: TT + TC versus CC (genotype 1); TNFA rs1800629: GG versus GA + AA (genotype 2)), age at baseline (five-year increments), and functional status at baseline (KPS score, ten-point increments).
Abbreviations; CI =confidence interval; GMM = growth mixture model; CESD = Center for Epidemiological Studies -Depression scale; IL1R2 = interleukin 1 receptor 2; IL10 = interleukin 10; KPS = Karnofsky Performance Status; TNFA = tumor necrosis factor alpha.