Table 1. Relative Hepatic mRNA Expression Involved in Lipid Metabolism in Mice Fed on a HFD with or without 25HCDS.
| Gene Name | Gene description | HFD (n = 6) | HFD+25HCDS (n = 7) |
| Fatty acid biosynthesis | |||
| SREBP-1c | Sterol regulatory element-binding protein-1c | 1.0±0.36 | 0.64±0.14 * |
| ACC1 | Acetyl-CoA carboxylase 1 | 1.0±0.31 | 0.86±0.18 |
| FAS | Fatty acid synthase | 1.0±0.27 | 0.68±0.17 * |
| Triglyceride metabolism | |||
| GPAM | Glycerol-3-phosphate acyltransferase | 1.0±0.10 | 0.74±0.18 * |
| MTTP | Microsomal triglyceride transfer protein | 1.0±0.11 | 0.94±0.17 |
| PLTP | Phospholipid transfer protein | 1.0±0.32 | 0.68±0.21 * |
| Cholesterol Metabolism | |||
| SREBP-2 | Sterol regulatory element-binding protein-2 | 1.0±0.18 | 1.12±0.25 |
| HMGR | Hydroxy-methylglutaryl-coenzyme A reductase | 1.0±0.16 | 0.84±0.07 |
| LDLR | Low density lipoprotein receptor | 1.0±0.43 | 0.62±0.08 * |
| CD36 (FAT) | Fatty acid translocase | 1.0±0.52 | 0.69±0.29 |
Animals were treated as described in Methods.
All values are expressed as the mean ± SD; n = 6–7.
* p<0.05 compared with HFD mice.
Abbreviations: HFD, high fat diet.