Table 1.
MiRNAs from tumor-derived exosomes isolated from different body fluids or cell types with potential use as biomarkers
| Tumor type | Relevant miRNA content | Sample or cell of origin | Study |
|---|---|---|---|
| Lung adenocarcinoma | miR-17-3p, miR-21, miR-106a, miR-146, miR-155, miR-191, miR-192, miR-203, miR-205, miR-210, miR-212, miR-214 | Peripheral blood | Rabinowits et al75 |
| Non-small-cell lung cancer | let-7f and miR-30e-3p | Plasma | Silva et al91 |
| Lung adenocarcinoma | miR-21, miR-133b, miR-98, and miR-181a | Lung cancer cell line: A549 | Xiao et al93 |
| Lung squamous cell carcinoma | miR-205, miR-19a, miR-19b, miR-30b, and miR-20a | Plasma | Aushev et al94 |
| Lung adenocarcinoma | miR-378a, miR-379, miR-139-5p, and miR-200b-5p; miR-151a-5p, miR-30a-3p, miR-200b-5p, miR-629, miR-100, and miR-154-3p | Plasma | Cazzoli et al95 |
| GBM | miR-21 | Serum | Skog et al,33 |
| GBM | miR-1469, miR-320b, miR-320c, miR-191, miR-222, Let-7a, miR-923, miR-1308, miR-3185, miR-351-5p, miR-25, miR-939, miR-30c, miR-422a, miR-221, miR-487a, miR-335*, and miR-4329 | GBM cell lines: LN18 and U87MG | Arscott et al,96 |
| Gastric cancer | miR-214, miR-221 and miR-222 | Cancer tissue-derived mesenchymal stem cells | Wang et al11 |
| Breast cancer | miR-16, miR-1246, miR-451 and miR-720 | Breast cancer cell line MCF7 cells, breast ductal lavages, milk and blood | Pigati et al56 |
| Breast cancer | miR-200a, miR-200c and miR-205 | Serum | Rupp et al97 |
| Basal-like ductal breast carcinoma | miR-140, miR-29a, and miR-21 | Tumor isolated CD49f+/CD24− stem-like cells | Li et al98 |
| Prostate cancer | miR-141 | Serum | Mitchell et al66 |
| Prostate cancer | miR-4258, miR-711, miR-221, miR-193a-3p, miR-30e, miR-1297, miR-129* and miR-21* | Prostate cancer cell line: PC3 | Hessvik et al99 |
| Prostate cancer | miR-485-3p | Prostate cancer cell line: DU-145 | Lucotti et al100 |
| Prostate cancer | miR-107, miR-141, miR-375, and miR-574-3p | Blood, urine sediment and tissue | Bryant et al101 |
| Ovarian cancer | miR-21, miR-141, miR-200a, miR-200c, miR-200b, miR-203, miR-205, and miR-214 | Serum | Taylor et al32 |
| Cervical cancer | miR-21 and miR-146a | Cervicovaginal lavage | Liu et al102 |
| Esophageal squamous cell carcinoma | miR-21 | Serum | Tanaka et al106 |
| Hepatocellular carcinoma | miR-584, miR-517c, miR-378, miR-520f, miR-142-5p, miR-451, miR-518d, miR-215, miR-376a*, miR-133b, and miR-367 | Hepatocyte carcinoma cell line | Kogure et al79 |
Abbreviations: GBM, glioblastoma multiforme; miRNA, microRNA.