Table 2. The associations between amounts of daily cigarette consumption, serum cotinine, CYP2A6 genotypes, and abdominal obesity in 954 current male smokers with blood samples.
Number (%) | Abdominal obesity | Amounts of daily cigarette consumption (>15 cigarettes/day) | Serum cotinine (≥225.31 ng/ml) | |
---|---|---|---|---|
Adjusted OR (95% CI) | Adjusted OR (95% CI) | Adjusted OR (95% CI) | ||
Amounts of daily cigarette consumption | ||||
1–15 cigarettes/day | 545 (57.1) | 1 | ||
>15 cigarettes/day | 409 (42.9) | 1.57* (1.13–2.19)a | ||
Serum cotinine | ||||
<225.31 ng/ml | 477 (50.0) | 1 | 1 | |
≥225.31 ng/ml | 477 (50.0) | 0.61* (0.41–0.90)b | 2.53* (1.92–3.32)c | |
CYP2A6 genotypes | ||||
CYP2A6 normal metabolizer genotype | 441 (46.2) | 1 | 1 | 1 |
CYP2A6 intermediate metabolizer genotype | 137 (14.4) | 0.72 (0.41–1.26)a | 1.03 (0.70–1.53)c | 1.08 (0.73–1.60)c |
CYP2A6 slow metabolizer genotype | 254 (26.6) | 0.90 (0.57–1.41)a | 0.89 (0.65–1.22)c | 0.89 (0.65–1.22)c |
CYP2A6 poor metabolizer genotype | 122 (12.8) | 0.94 (0.53–1.66)a | 0.59* (0.38–0.90)c | 0.52* (0.34–0.79)c |
p<0.05
Binary logistic regression adjusted for age, occupation, education, family income, alcohol consumption, exercise, coffee consumption, tea consumption, and BMI
Binary logistic regression adjusted for age, occupation, education, family income, alcohol consumption, exercise, coffee consumption, tea consumption, daily cigarettes consumption, and BMI
Binary logistic regression adjusted for age, occupation, education, family income, alcohol consumption, exercise, coffee consumption, and tea consumption