Table 3.
The 13-protein logistic regression classifier.
| Protein (Human) | Transition | Coefficient* | 95% CI* | p-value† | Tissue biomarker‡ | Biomarker in literature |
|---|---|---|---|---|---|---|
| LRP1 | TVLWPNGLSLDIPAGR_855.00_400.20 | −1.59 | (−2.39, −1.20) | 9.64E-05 | EPI | (38) |
| BGH3 | LTLLAPLNSVFK_658.40_804.50 | 1.73 | (1.18, 2.53) | 4.37E-03 | (39) | |
| COIA1 | AVGLAGTFR_446.26_721.40 | −1.56 | (−2.48, −1.16) | 3.90E-04 | (40) | |
| TETN | LDTLAQEVALLK_657.39_330.20 | −1.79 | (−2.95, −1.21) | 6.71E-03 | (41) | |
| TSP1 | GFLLLASLR_495.31_559.40 | 0.53 | (0.35, 0.93) | 1.13E-02 | (42) | |
| ALDOA | ALQASALK_401.25_617.40 | −0.80 | (−1.21, −0.51) | 1.03E-02 | Secreted, EPI | (43) |
| GRP78 | TWNDPSVQQDIK_715.85_260.20 | 1.41 | (0.91, 2.24) | 6.24E-03 | Secreted, EPI, ENDO | (44) |
| ISLR | ALPGTPVASSQPR_640.85_841.50 | 1.40 | (0.85, 2.21) | 1.09E-02 | ||
| FRIL | LGGPEAGLGEYLFER_804.40_913.40 | 0.39 | (0.24, 0.66) | 1.63E-02 | Secreted, EPI, ENDO | (45) |
| LG3BP | VEIFYR_413.73_598.30 | −0.58 | (−0.97, −0.28) | 6.24E-02 | Secreted | (46) |
| PRDX1 | QITVNDLPVGR_606.30_428.30 | −0.34 | (−0.64, −0.10) | 1.54E-01 | EPI | (47) |
| FIBA | NSLFEYQK_514.76_714.30 | 0.31 | (0.16, 0.53) | 4.10E-02 | (48) | |
| GSLG1 | IIIQESALDYR_660.86_338.20 | −0.70 | (−1.51, −0.19) | 1.60E-01 | EPI, ENDO | |
| Constant | 36.16 | (19.72, 59.01) |
*
Based on 20,000 Monte Carlo cross validation permutations with a 20% hold-out rate: “Coefficient” is the corresponding median values from the permutations, “95% CI” is the corresponding 95% BCa confidence intervals (49).
†
Based on likelihood ratio test on the whole discovery dataset, comparing the models with or without the corresponding proteins.
‡
See Supplementary Materials and Table S3 for details.