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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Obesity (Silver Spring). 2014 May 2;22(8):1847–1853. doi: 10.1002/oby.20773

Fig. 2.

Fig. 2

Brain infusion of SU9119 increases body weight of RYGB and sham-operated rats. a: Absolute body weight. b: Percent change of body weight from start of SHU9119 or vehicle infusion. Eight to twelve weeks after RYGB or sham surgery (Fig. 1), animals were implanted with lateral ventricular cannulas and after recovery adapted to metabolic chambers. The MC3/4 receptor antagonist SHU9119 (100 μg/day) or saline as vehicle was then infused via minipump for 14 days. Note that body weight of both RYGB and sham-operated rats steeply and significantly increased by infusion of SHU9119 but not saline vehicle and returned to near pre-infusion levels after 50–60 days. (n = 10 for each of the 4 treatment groups).