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. Author manuscript; available in PMC: 2015 Aug 15.
Published in final edited form as: Exp Cell Res. 2014 Apr 25;326(2):295–306. doi: 10.1016/j.yexcr.2014.04.013

Figure 5. Differential effects of FAK inhibitor on fibroblast contraction of floating collagen matrices in PDGF and FBS-containing medium.

Figure 5

Floating collagen matrix contraction was carried out in DMEM/PDGF and DMEM/FBS. FAK inhibitor PF-22 as indicated was added to the incubations at the time the matrices were released from the underlying culture dish to initiate contraction. Data shown are the appearance of collagen matrices from a representative experiment and the averages ± SD of quantitative contraction measurements (starting – final matrix diameter) for triplicate samples. FAK inhibitor PF-228 blocked PDGF-FMC but had no effect on FBS-FMC.