Table 1.

Summary of myosin II isoform functions in collagen matrix contraction¹

3D Collagen Matrix Model	Myosin II Isoform	Inhibition by Blebbistatin	Rho Effector
FBS -- Stressed Matrix Contraction	IIA	2.5 – 5.0 μM	Rho Kinase [22,37]
PDGF -- Floating Matrix Contraction	IIA or IIB	2.5 – 5.0 μM	Rho Kinase [22,26]
FBS -- Floating Matrix Contraction	Neither IIA or IIB	10 – 20 μM	mDial [26]
FBS -- Cell Clustering with Cells on Top of Matrix	IIA	2.5 – 5.0 μM	Rho Kinase [25]
FBS -- Matrix Flattening with Cells on Top of Matrix	Neither IIA or IIB	20 – 40 μM	not tested

¹See text for details