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. 2014 Jul 30;34(31):10247–10255. doi: 10.1523/JNEUROSCI.1680-14.2014

Figure 4.

Figure 4.

BNST acidosis evokes ASIC1A-dependent freezing. A, Schematic of experimental design with fiberoptic pH sensors implanted in BNST or amygdala, showing that infusion of low pH solution into the BNST acidifies the BNST but not the amygdala. B, Diagram of acid infusion sites; BNST (circles) versus extra BNST (diamonds) (Paxinos and Franklin, 2001). C, Freezing behavior after infusion of low pH solution or normal pH solution in cases that hit or missed the BNST. Infusing low pH solution evoked a freezing response in ASIC1A+/+ mice that was largely absent in Asic1a−/− mice. Low pH infusions into the BNST of Asic1a+/+ mice evoked significantly more freezing than in Asic1a−/− mice. In Asic1a+/+ mice, low pH infusions hitting the BNST elicited significantly more freezing than those that missed the BNST.