Figure 3.

IFNγ reduces OD plasticity in WT mice by impairing open-eye responses. A, ODI in WT mice during the critical period with no MD, 7 d MD, or 7 d MD with additional concurrent IFNγ treatment (no MD, 7 d MD, and 7 d MD plus IFNγ, n = 10, 4, and 4 animals, respectively). B, Response amplitude for the contralateral (Contra) and ipsilateral (Ipsi) eyes in WT mice. C, ODI in STAT1 KO mice with the same treatment as in A (no MD, 7 d MD, and 7 d MD plus IFNγ, n = 10, 4, and 3 animals, respectively). D, Response amplitude for the contralateral and ipsilateral eyes in STAT1 KO mice. In A–D, individual data points are plotted as circles, and asterisks above bars show statistical significance compared with no MD in each group. Averaged data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.