Figure 5.

Astrocyte hypertrophy is reduced in the KO animals. GFAP-immunoreactivity at the indicated postinjury survival times in control and β-catenin KO animals. Insets show higher magnification views of the boxed areas. Astrocytes are hypertrophic at 5 dpi in the control animals but appear unchanged in the KO animals. At 20 dpi, astrocytes form a compact border around at the injury site; KO astrocytes are irregular in appearance and do not form a compact border. Scale bars: A, 50 μm; insets, 10 μm.