Comparison of neuron numbers in nodose ganglia of control and INT-BDNF−/− mice. Representative images of the right nodose ganglion are shown in a control (A) and an INT-BDNF−/− (B) mouse. The total (left and right nodose ganglia combined) and the right nodose demonstrated significant increases in vagal sensory neuron number in INT-BDNF−/− mice (n = 14) compared with controls (n = 9, 47% and 62% increases, respectively; both p < 0.05; C), whereas the left nodose ganglia showed a nonsignificant 25% increase in neuron number in INT-BDNF−/− mice. Scale bar: (in B) A, B, 150 μm.