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. 2014 Jul 30;34(31):10402–10414. doi: 10.1523/JNEUROSCI.0911-13.2014

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Copyright © 2014 the authors 0270-6474/14/3410402-13$15.00/0

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Figure 8. — Regulation of glutamate release onto VTA dopamine neurons via CRF. Top, Under normal conditions, presynaptic CRF-R1 potentiates glutamate release onto AMPA receptors on dopamine neurons. CRF-R2 activation potentiates GABA release, which activates postsynaptic GABA-A receptors and presynaptic GABA-B receptors on glutamatergic terminals. Bottom, After cocaine-self-administration, GABA release is potentiated, suppressing glutamate release. After yohimbine plus cue-induced reinstatement, CRF-R2 activation decreases GABA release via an adenosine receptor-dependent mechanism.