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. 2014 Jul 22;9:103. doi: 10.1186/s13023-014-0103-y

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Copyright © 2014 López-Lera et al. ; licensee Biomedcentral Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Bisulphite sequencing. Chromatograms showing the results of bisulphite sequencing in: (A) Huh7 hepatoma cells in CpG islands 1 and 2 (left and right panels, respectively), (B) Sequence of the bisulphite-modified CpG island 1 in type I and type II HAE patients (left and right panels, respectively) and (C) CpG island 2 type I and type II HAE patients (left and right panels, respectively) (C). Arrows indicate the CpG positions susceptible of methylation. Wild Type sequences are: CpG Island 1: tgggctcccagggtgggagCtggctcCGaggctggctggctcCGcaggtcCGctgaCG. CpG Island 2: tggaggcCGaggCGggtggatcaCGaggtcaggagatCGagacccatcctggctaacaCG.