Table 1.

Distribution of number of treatment lines by patient-level factors

Total (N = 7,950)	No Tx		Tx1 only			Tx2
	(N = 4,684)		(N = 1,826)			(N = 1,440)
	N	Col %	N	Col %	p*	N	Col %	p †
CCI
CCI = 0	2,667	57	1,160	64	<0.0001	975	68	0.014
CCI = 1	1,023	22	424	23		312	22
CCI = 2	530	11	150	8		97	7
CCI = ≥3	464	10	92	5		56	4
Poorly graded tumor
Yes	1,105	24	542	30	<0.0001	395	27	0.033
No	3,579	76	1,284	70		1,045	73
Surgery of primary site
Yes	2,293	49	1,295	71	<0.0001	1,139	79	<0.0001
No	2,391	51	531	29		301	21
Surgery of liver metastases
Ablation of liver metastasis	319	7	257	14	<0.0001	211	15	0.515
Surgery to other site(s)	173	4	98	5		64	4
None	4,192	90	1,471	81		1,165	81
Proxy for poor performance status
Yes	601	13	104	6	<0.0001	44	3	<0.0001
No	4,083	87	1,722	94		1,396	97
Age at time of Dx
66–74	1,100	23	809	44	<0.0001	797	55	<0.0001
75–84	2,057	44	841	46		592	41
≥85	1,599	33	176	10		51	4
Female
Yes	2,671	57	952	53	<0.0001	708	49	0.004
No	2,013	43	874	47		732	51
Married
Yes	1,739	37	992	54	<0.0001	905	63	<0.0001
No	2,945	63	834	46		535	37
Urban living area
Yes	4,197	90	1,620	89	0.068	1,309	91	0.021
No	487	10	206	11		131	9
Race/ethnicity
Non-Hispanic White	3,665	78	1,470	81	0.003	1,191	83	<0.0001
African American	592	13	184	10		122	8
Hispanic	218	5	94	5		62	4
Asian	209	4	78	4		65	5

CCI Charlson comorbidity index, CoI column, Dx diagnosis, Tx treatment, Tx1 first-line treatment, Tx2 second-line treatment

* p measures the statistical significance of the difference between column percentages of no Tx group and another group (i.e., Tx1 only and Tx2 and above)

^† p measures the statistical significance of the difference between column percentages of Tx1 only and Tx2