Table 2.

Individual cases of neurodevelopmental disorder alongside demographic information

	Diagnosis	Gender	AED	Dose (mg daily)	Maternal Epilepsy Type	Seizures	Congenital Malformation	Maternal age	Paternal age	Siblings with ASD■	Alcohol	Nicotine
	Autistic Spectrum Disorders
1	Aspergersđ	M	VPA	1000	IGE	1TC	Multiple minor	33	39	None	Yes	No
2	Autism đ	M	VPA	600	F	1 PS+SG	None	27	29	1sibling (VPA exposed)	No	No
3	Autismđ	M	VPA	1,500	F	2PS+SG	None	22	30	None	No	Yes
4	Pervasive Developmental Disorderđ	M	VPA	2500	IGE	2TC	None	23	29	None	Yes	Yes
5	Autism đ	F	VPA+LTG	2000+100	F	2TC	None	26	37	None	No	No
6	Aspergersđ	M	LTG	500	F	1PS+SG	None	30	31	None	No	No
7	Aspergers & ADHD	F	VGB	4000	F	2TC	None	19	Not known	None	No	Yes
8	Autismđ	M	PHT	300	F	0	None	35	Not known	None	Yes	Not known
9	Autismđ	M	Control	N/A	N/A	N/A	None	32	Not known	None	Yes	No
10	Aspergersđ	M	Control	N/A	N/A	N/A	None	31	32	None	No	No
11	Aspergersđ	F	Control	N/A	N/A	N/A	None	32	31	1 sibling	No	No
12	Autism	M	Control	N/A	N/A	N/A		37		None	No	Yes
	ADHD
13	ADHD	M	VPA+LTG	2000+50	IGE	0	1 major	27	40	2 Siblings (VPA exposed)	No	No
14	ADHD○	F	CBZ	1200	F	0	None	24	31	None	No	No
15	ADHD	M	VPA+LTG	1500+25	F	2TC	None	18	Not known	None	Yes	No
	Dyspraxia
16	Dyspraxia	M	LTG	100	F	2 TC	None	22	Not known	None	No	No
17	Dyspraxia	M	VPA	600	IGE	0	None	26	30	None	No	No
18	Dyspraxia	M	CBZ+LTG	600+50	UC	2TC	Isolated minor	24	Not known	None	No	No
19	Dyspraxia	M	VPA	1000	UC	2TC	None	40	Not known	None	No	No

^đ Case was included in the preliminary report from this cohort (26).

^○ Child also has idiopathic generalised epilepsy. IGE- Idiopathic generalised epilepsy, F- focal, UC – unclassified, PS – partial seizures, TC- tonic clonic seizures. Alcohol includes intake prior to knowledge of conception. Nicotine – smoking even prior to knowledge of conception.

^■ ASD was the only reported diagnosed disorder in siblings.