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. 2014 Jul 17;10(8):807–816. doi: 10.7150/ijbs.9143

Figure 1.

Figure 1

Somatic mutations of human SAMD9L and SAMD9 in HCC samples. (A) The somatic mutation distribution of human SAMD9L and SAMD9 genes in the liver cancer samples, including in-house HCC specimens and other liver carcinoma samples deposited in COSMIC (Catalogue Of Somatic Mutations In Cancer, http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/) database, is shown on a schematic describing genomic structures and transcripts of human SAMD9L and SAMD9 genes. The two genes contain a well conserved sterile alpha motif (SAM) domain, as indicated by red boxes in their protein-coding transcripts. The amino acid variations resulted from somatic mutations are shown for the two genes; confirmed somatic mutations were marked by red and in-house confirmed variations are indicated by symbol “†”. (B) DNA sequence chromatograms of SAMD9L mutations in HCC cohort examined. Red triangles indicate the mutation sites. N: adjacent non-cancerous liver, C: primary HCC specimen, S: PVTT (portal vein tumor thrombus) specimen. (C) The relationship between those HCC cases with TP53, ARID1A and SAMD9L mutation in 110 in-house HCC specimens, of which 35 carried TP53 mutation (Mut), 14 ARID1A Mut and 6 SAMD9L Mut.