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. 2014 Jul 10;10(7):777–788. doi: 10.7150/ijbs.9220

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 4 — Effect of carbon monoxide releasing molecule-2 (CORM-2) on mitochondrial number in the heart of septic mice. Mice were challenged with CLP and treated with CORM-2 or iCORM-2. 24 h following CLP surgery, mitochondrial number was assayed by mitotracker green staining and mtDNA copy number. Accumulation of mitotracker was detected by confocal microscopy. Representative images and mean Fluorescence Intensity were shown in A and B. Results showed that CLP significantly reduced the accumulation of mitotracker compared with sham mice. Administration of CORM-2 significantly reversed the loss of mitotracker. C, mtDNA copy number was also reduced in CLP challenged mice while CORM-2 significantly abolished this reduction. Data were shown as mean ± SD, ^**P < 0.01 compared with sham, ^***P < 0.001 compared with sham, ^#P < 0.05 compared with CLP, ^###P < 0.001 compared with CLP.