Fig 5.

Effect of carbon monoxide releasing molecule-2 (CORM-2) on FDG uptake, ATP and lactate content in the heart of septic mice. Mice were challenged with CLP and treated with CORM-2 or iCORM-2. A, Representative images of Positron Emission Tomography (PET) scanning. B, Standardized uptake value (SUV) results displayed that CLP mice had higher ¹⁸F-fluorodeoxyglucose (FDG) uptake than that in sham mice at 24 h after CLP injury. After in vivo administration of CORM-2, FDG uptake was significantly decreased. C, Cardiac ATP content was slightly but significantly lower in CLP mice as compared with sham mice at 24 h after CLP surgery. With the treatment of CORM-2, ATP content was significantly increased. D, Production of lactate was low in sham group. After CLP challenge, lactate levels were significantly increased whereas administration of CORM-2 markedly decreased lactate production. Data were shown as mean ± SD, ^*P < 0.05 compared with sham, ^***P < 0.001 compared with sham, ^#P < 0.05 compared with CLP.