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. 2014 Jul 10;10(7):777–788. doi: 10.7150/ijbs.9220

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Fig 8 — Effect of carbon monoxide releasing molecule-2 (CORM-2) on mitochondrial biogenesis genes in the heart of septic mice. Mice were challenged with CLP and treated with CORM-2 or iCORM-2. Expression of PGC-1α, NRF-1, NRF-2 and Tfam mRNAs were detected by RT-qPCR. A, Results showed that CLP surgery did not changed the expression of PGC-1α, however CORM-2 treatment significantly up-regulated the expression of PGC-1α at 6, 12 and 24 h after CLP surgery. B, NRF-1 genes were not changed in CLP challenged group but significantly up-regulated at 12 and 24 h after CLP surgery in the presence of CORM-2. C, NRF-2 genes were not alterated among all groups. D, Tfam genes were down-regulated at 24 h after CLP challenge, and CORM-2 treatment significantly reversed this decline. Data were shown as mean ± SD, ^#P < 0.05 compared with CLP, ^##P < 0.01 compared with CLP.