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Plot of pituitary size (Z-score) versus pituitary iron[58, 60]. No pituitary dysfunction was observed when size and iron Z-scores were normal (green) or even when pituitary iron was moderately elevated (Z score 2 to 5, yellow zone)[58]. However, hypogonadism was common (50%) in severe pituitary iron overload (Z > 5, red zone) or when the pituitary gland was shrunken (Z score < −2.0).
