Fig. 2.

An overview of how information accumulates in kinase research from 1975 to 2013. (A) For each kinase we summed the number of publications available (x-axis) and the number of publications disclosing an interaction for this kinase (y-axis). Each dot is thus a kinase and we see a strong correlation (red line) between the two types of knowledge (general and protein interaction). The correlation is preserved but weaker for low abundant and not commonly expressed kinases (yellow dots, green line). (B) Same analysis as in (A) but developing for each kinase a cumulative time course showing how knowledge increases over time (the end point of each curve is a dot in panel A). K-means clustering with three clusters was used to color lines (red, yellow, green). Cluster averages were featured with thick lines. (C) Focus of the community for cancer-related kinases is significantly less pronounced in protein interaction research.