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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Hepatology. 2014 Mar 27;59(5):1886–1899. doi: 10.1002/hep.26954

Fig. 5.

Fig. 5

Upregulation of MDM4 in AKT mice. (A) Representative Western blots in wild-type and mice (12 and 28 weeks old). (B) The densitometric analyses reveal a co-regulation of pAKT, USP2a, and MDM4, while the MDM4 transcription (C) is not altered between wild-type and animals. (D) Representative immunohistochemicial stainings of wild-type (left panel) and AKT (right panel) for pAKT (upper panel) and MDM4 (lower panel). Original magnification: 20×. (E) Representative Westernblots in AKT transgenic mice treated with vehicle or Rapamycin. Abbreviation: wks, weeks; WT, wildtype.