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. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: Circulation. 2014 May 23;130(5):431–441. doi: 10.1161/CIRCULATIONAHA.113.006720

Figure 2.

Figure 2

Inhibition of Enterocyte ApoB Secretion by Acute Deletion of PCSK9 Gene Expression. CaCo-2 cells treated with PCSK9 siRNA (15 nmol/L, 48 hours) showed a 70% reduction in PCSK9 mRNA expression versus CaCo-2 cells transfected with a negative control vector, and demonstrated no significant decline in cellular viability versus untreated cells (results not shown). PCSK9 siRNA knockdown resulted in a nearly 40% decrease in both apoB48 and apoB100 secretion from CaCo-2 cells.