. Author manuscript; available in PMC: 2014 Jul 30.

Published in final edited form as: Immunol Cell Biol. 2008 Feb 26;86(4):301–309. doi: 10.1038/icb.2008.6

Table 2.

Abnormalities in Hox11 derivative tissues

	Abnormal cell structures mouse strains			Organ malfunction mouse strains
	NOD	NOD-SCID	Control C57	NOD	NOD-SCID	Control C57
					Deafness^a
Cochlea/ear	Abnormal 100% n=13	Abnormal 100% n=10	Normal <22% n=8	Abnormal 100% n=13	Abnormal 100% n=10	Normal 0% n=8
					Diabetes^b
Pancreas	Abnormal 100% n=15	Abnormal 100% n=18	Normal 0% n=18	Abnormal >85% n=56	Normal 0% n=15	Normal 0% n=15
					Salivary flow^c
Salivary gland	Abnormal 100% n=8	Abnormal 100% n=9	Normal 0 n=8	Abnormal >90% n=5	Normal 0% n=5	Normal 0% n=14
Tongue	Abnormal 100% n=6	Abnormal 100% n=2	Normal 100% n=4	NA	NA	NA

Abbreviation: NA, not applicable.

Control mice in this study were C57BL/6 mice, sex and age matched to the NOD and NOD-SCID.

All cell structure comparisons in this table represent mice at 5–8 weeks of age.

Hearing was monitored by ABR as described in the Methods at 5–8 weeks of age.

Incidence of diabetes was monitored in female mice from about 15 weeks of age until diabetes, typically at 25 weeks of age.

Salivary flow was monitored in mice after 12 weeks of age by the pilocarpine salivary flow test.