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. Author manuscript; available in PMC: 2014 Jul 30.
Published in final edited form as: Curr Allergy Asthma Rep. 2011 Oct;11(5):388–394. doi: 10.1007/s11882-011-0210-y

Fig. 1. The development of IL-17-producing T cells and the severity of asthma.

Fig. 1

Upon exposure to allergens and infectious agents, dendritic cells activated by TSLP (thymic stroma lymphopoietin) or anaphylatoxin C3a can induce naïve T cells to differentiate into TH2 or TH17 cells, respectively. Depending on the inflammatory signals in the microenvironment, local TH2 memory/effector cells may acquire distinct inflammatory properties to become IL-17-producing cells that promote severity of asthma.