Fig. 1.
Redundancy between Celsr2 and Celsr3 in constitutive mutants at P0. Whereas no anomaly of axonal bundles is seen in Celsr2gt/gt brains (A and E) (n = 4), profuse defects are present in Celsr3−/− (B and F) as described (2). Celsr2 and 3 double mutants (C and G) (n = 6) display additional defects that mimic those in Fzd3−/− mice (D and H) (n = 3). (A–D) H&E staining; (E–H) neurofilament immunohistochemistry. fr, fasciculus retroflexus; ml, medial lemniscus; mt, mammillothalamic tract; sm, stria medullaris. (Scale bar: 500 µm.)