Skip to main content
. 2014 Jul 7;111(29):E2996–E3004. doi: 10.1073/pnas.1402105111

Fig. 8.

Fig. 8.

Abnormal organization of the barrel field upon combined inactivation in cortex and thalamus. (A and B) In control mice, the somatosensory map, studied using vGlut2 immunostaining (“presynaptic” component, green) and DAPI (“postsynaptic” component, blue) at P8, appears normal, with five rows of barrels (A–E) in the posteromedial subfield corresponding to whiskers (A, tangential section) and vGlut2-positive TCA terminal clusters in layer IV (B, coronal section). In contrast, the barrel fields are diminutive and architectonically disorganized when Celsr2+3 (C and D) (n = 11) or Fzd3 (E and F) (n = 3) are jointly inactivated in both cortex (Nex-Cre) and thalamus (Foxb1-Cre). The vGlut2-positive TCA terminals do not form clear clusters in layer IV in both mutants (D and F). Asterisks: anterolateral fields; II/III, IV, V: cortical layers. [Scale bars: 500 µm (A, C, and E); 200 µm (B, D, and F).]