Table 1.

Summary of cortical and thalamic projection phenotypes

Genotype	Wiring phenotype
Celsr2gt/gt	No phenotype (Fig. 1 A and E)
Celsr2gt/gt;Celsr3−/−	Full defect of IC (Fig. 1 C, D, G, and H)
Celsr2−/−;Celsr3−/−
Fzd3−/−
Celsr2gt/gt;Emx1-Cre;Celsr3f/−	Decreased IC with partially blocked/delayed TCA (Figs. 2 and 4 B and E)
Emx1-Cre;Celsr2f/−;Celsr3f/−	Looping of TCA in external basal forebrain (Fig. 2 and Fig. S2D)
Nex-Cre;Celsr2f/−;Celsr3f/−	Absence of CST (Fig. 4H)
Emx1-Cre;Fzd3f/−	Layer 5 axons routed to thalamus (Fig. 7H)
Nex-Cre;Fzd3f/−	Normal barrel field (Fig. S5 A, B, E, and F)
Foxb1-Cre;Celsr2f/−;Celsr3f/−	No phenotype (Fig. 5 A, C, E, G, I, and K and Fig. S5 C, D, G, and H)
Foxb1-Cre;Fzd3f/−
Nex-Cre;Foxb1-Cre;Celsr2f/−;Celsr3f/−	Decreased IC with partially blocked/delayed TCA (Fig. 5 B, D, F, and H)
Nex-Cre;Foxb1-Cre;Fzd3f/−	Looping of TCA and CTA in external basal forebrain (Figs. 5 and 6)
	Absence of CST (Fig. 5 J and L)
	Layer 5 axons routed to thalamus (Fig. 7I)
	Abnormal barrel field (Fig. 8)