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. 2014 Jun 30;111(29):10514–10519. doi: 10.1073/pnas.1402216111

Fig. 3.

Fig. 3.

Optimization of hydrogel composition for conformal coating of islets. (A) Effect of percentage of PEG-VS (P > 0.05). (B) Effect of coating thickness: conformal coating (CC) vs. macrocapsule (MACRO, diameter: 600–1,000 μm). (C and D) Effect of saturating (CAP) zero, two, or four of the eight functional groups of PEG-VS with CC. (E) Combined effect of cross-linker: DTT vs. 1-kDa linear PEG dithiol (HS-PEG-SH) vs. four-arm 10-kDa or 20-kDa PEG-SH and of PEG-VS percentage: 10% vs. 5%. (F) Effect of ALG (MVG) addition. Shown are mean ± SD with n = 3 for each value. (G) Diffusion of 10-kDa FITC-dextran outside of hydrogel microparticles with different PEG compositions as indicated by c/cinf over time. c, concentration; cinf, concentration of dextran at equilibrium. LG = 2.2 mM and HG = 16.7 mM. *P < 0.05; ***P < 0.01.